Researchers in Sweden and Finland have found several genes that lead to increased risk for a systemic lupus erythematosus (SLE)-like autoimmune disorder in dogs. This is the first time scientists have found genes behind such a complex disease. The study indicates that the homogeneity of strong genetic risk factors within dog breeds make dogs an excellent model in which to identify pathways involved in human complex diseases. The results of the study also open the door for further studies of specific T-cell activation pathways in human populations.
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