Placental Precursor Stem Cells Require Testosterone-free Environment To Survive

Trophoblast stem cells, found in the layer of peripheral embryonic stem cells from which the placenta is formed, are thought to exhibit “immune privilege” that aids cell survivability and is potentially beneficial for cell and gene therapies. Survivability of TSCs has been thought to require the presence of ovarian hormones. This study, however, demonstrates that it is the absence of male hormones, rather than the presence of female hormones, that allows extended transplanted cell survivability.